The crazy people at Waterloo Labs developed a system to play the computer game Half-Life, a First Person Shooter, using accelerometers, drywall and a integrally suppressed Ruger MKIII.
Looks like a lot of fun!
A parts list and computer code to build a similar system can be found at Waterloo Labs.
Many thanks to Antonio for the link.
UPDATE: Nookyon points out in the comments that the game appears to be a flash based “remake” of Half Life, not the original.