Hornady has announced a new .410 defensive handgun load in their Critical Defense line. The 410 Triple Defense has a 115 grain .41 Caliber FXT slug backed by two .35 caliber lead balls (.35 caliber is just slightly smaller than 000 buck shot). The FXT slug will engage the rifling of a Taurus Judge.
The penetration and accuracy can be seen in the video below. It looks impressive to me.