A Arfcomer decided to see what would happen if he loaded a .45 ACP case with as much powder as he could squeeze in and then fired it in a Hi-Point .45 pistol. His load was ….
Speer large primer .45 case, CCI large pistol primer, 230GR LRN bullet loaded to 1.250 oal, 23 grains bullseye.
The official Alliant Powder (manufacturers of Bullseye) load for a .45 ACP loaded with a 230 grain bullet is 5 grain of Bullseye. He managed to load more than four times the recommended weight of powder.
I don’t think science has been advanced by this experiment.
[ Many thanks to jdun1911 for emailing me the link. ]